Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.080 Biomarker BEFREE • Combining metabolical and morphological features using<sup>18</sup>F-FDG PET/CT improves the detection of malignant lymph node in patients with bladder cancer. 30666449

2019

Entrez Id: 2146
Gene Symbol: EZH2
EZH2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 Biomarker BEFREE  Effect of siRNA targeting EZH2 on cell viability and apoptosis of bladder cancer T24 cells. 25501205

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 AlteredExpression BEFREE Zymography revealed higher levels of MMP-9 activity in the ovarian cancer biopsy samples than in other cancers studied, but in contrast to our previous observations in breast and bladder cancer, there was no correlation between MMP levels and tumor grade. 8014015

1994

Entrez Id: 6624
Gene Symbol: FSCN1
FSCN1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.050 AlteredExpression BEFREE ZEB1-AS1 functions as a competing endogenous RNA in BLCA to regulate the expression of fascin-1 through miR-200b. 30823924

2019

Entrez Id: 9201
Gene Symbol: DCLK1
DCLK1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.020 Biomarker BEFREE Yet, there are limited reports on the role of DCLK1 as a putative CSC marker in bladder cancer. 31028726

2019

Entrez Id: 7515
Gene Symbol: XRCC1
XRCC1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 Biomarker BEFREE XPD and XRCC1 appear to have no impact on the risk of bladder cancer. 11304692

2001

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.050 AlteredExpression BEFREE XPC deficiency leads to centrosome amplification by inhibiting BRCA1 expression upon cisplatin-mediated DNA damage in human bladder cancer. 30579971

2019

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 Biomarker BEFREE XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion. 31811115

2019

Entrez Id: 1869
Gene Symbol: E2F1
E2F1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.090 Biomarker BEFREE XIAP Interaction with E2F1 and Sp1 via its BIR2 and BIR3 domains specific activated MMP2 to promote bladder cancer invasion. 31811115

2019

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 AlteredExpression BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023

2017

Entrez Id: 406983
Gene Symbol: MIR200A
MIR200A
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.040 AlteredExpression BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023

2017

Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.020 AlteredExpression BEFREE XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. 28057023

2017

Entrez Id: 2068
Gene Symbol: ERCC2
ERCC2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.400 GeneticVariation BEFREE Xeroderma pigmentosum complementation group D (XPD) gene polymorphisms contribute to bladder cancer risk: a meta-analysis. 24347488

2014

Entrez Id: 283624
Gene Symbol: LINC00641
LINC00641
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.020 AlteredExpression BEFREE Xenograft assay also confirmed that LINC00641 overexpression suppressed bladder cancer growth in vivo. 30060954

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.100 Biomarker BEFREE X-ray-induced intrachromosomal DNA rearrangements were detected in the 5' region of the MYC gene of cells of the human bladder carcinoma cell line, EJ-30, by using PCR with inverted primers. 10453083

1999

Entrez Id: 2463
Gene Symbol: FRA16D
FRA16D
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 AlteredExpression BEFREE WW domain-containing oxidoreductase (WWOX) gene located in the common fragile site FRA16D region exhibits loss or reduction of expression in multiple types of carcinomas including bladder cancer. 27352332

2015

Entrez Id: 442919
Gene Symbol: MIR374A
MIR374A
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 Biomarker BEFREE WNT5A was a direct target of miR-374a in two bladder cancer cell lines. miR-374a mimic abrogated the metastatic potential and invasiveness of bladder cancer cells via WNT5A downregulation in both T24 and TCCSUP human bladder cancer cells; the opposite was observed with miR-374a inhibitor. 30032142

2018

Entrez Id: 142
Gene Symbol: PARP1
PARP1
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.040 GeneticVariation BEFREE Without adjustment for multiple testing, multivariate analysis demonstrated an association with increased bladder cancer risk with PARP1 rs8679 (P(trend) = 0.05) while variant homozygotes of PARP1 rs8679 were also noted to have an increased breast cancer risk (P = 0.03). 22166496

2012

Entrez Id: 1544
Gene Symbol: CYP1A2
CYP1A2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.090 GeneticVariation BEFREE Within the framework of a hospital-based case/control study, we investigated the relationship between CYP1A2 polymorphisms, occupational/environmental exposures and bladder cancer (BC) risk. 20559687

2010

Entrez Id: 8091
Gene Symbol: HMGA2
HMGA2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.040 Biomarker BEFREE WITHDRAWN: Long non-coding RNA UCA1 regulates tumor growth by impairing let-7e-dependent HMGA2 repression in bladder cancer. 31306103

2019

Entrez Id: 406887
Gene Symbol: MIRLET7E
MIRLET7E
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 Biomarker BEFREE WITHDRAWN: Long non-coding RNA UCA1 regulates tumor growth by impairing let-7e-dependent HMGA2 repression in bladder cancer. 31306103

2019

Entrez Id: 4907
Gene Symbol: NT5E
NT5E
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.030 Biomarker BEFREE With the aim of using ecto-5'-nucleotidase/CD73 as a predictive biomarker, the role of this enzyme in the context of radiotherapy in T24 human bladder cancer cell line was investigated. 29305710

2018

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.080 GeneticVariation BEFREE With respect to the stage of BC, the AA genotype of SDF-1 and at least one T allele of CXCR4 were significantly associated with high T stage as compared to GG genotype of SDF-1 and CC genotype of CXCR4. 22982413

2012

Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.070 GeneticVariation BEFREE With respect to the stage of BC, the AA genotype of SDF-1 and at least one T allele of CXCR4 were significantly associated with high T stage as compared to GG genotype of SDF-1 and CC genotype of CXCR4. 22982413

2012

Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.060 Biomarker BEFREE With respect to TIMP-2 blood and urine levels, results showed a significant decrease in gene expression levels in bladder carcinoma group, whereas, TIMP-2 protein showed a significant increase in bladder carcinoma. 30548095

2019